Fusobacterium necrophorum

  • General information

    • the following information is not yet verified
      Family: Fusobacteriaceae

      2 subspecies:
      F. necrophorum subsp fundiliforme (biovar B) dominant isolate in humans
      F. necrophorum subsp necrophorum is a commonly pathogen in animals

      Natural habitats
      Mainly isolated from the oral cavity

      Clinical significance
      This bacterium is extremely virulent and caused very severe infections, mostly in children or young adults, coming through a pharynges tonsillitis.

      It was formerly the most anaerobic bacteria found in tonsillar abscesses of young adults.

      They also occur in abscesses in the lungs, pleura and liver.

      F. necrophorum is now less found than in the era before the use of antibiotics, so this bacterium is very treacherous, because doctors are not familiar with F. necrophorum.

      A Gram-stained smear with highly pleomorphic Gram-negative rods in a positive blood culture bottle from a septic patient following a sore throat may indicate invasive Fusobacterium necrophorum infection.

      Lemierre syndrome
      Develops most often after a strep sore throat has created a peritonsillar abscess, anaerobic bacteria like Fusobacterium necrophorum can flourish.

      The bacteria penetrate from the abscess into the neighboring jugular vein in the neck and there they cause an infected clot (thrombosis) to form, from which bacteria are seeded throughout the body by the bloodstream (bacteremia).

      Pieces of the infected clot break off and travel through the lungs as emboli blocking branches of the pulmonary artery bringing the heart’s blood to the lungs.

      This causes shortness of breath, chest pain and severe pneumonia.

  • Diseases

  • Gram stain

    • the following information is not yet verified
      Pleomorphic long Gram negative rods,

      with round ends and often has bizarre forms,

      with sometimes round bodies.

  • Culture characteristics

    • the following information is not yet verified

      Obligate anaerobic

      BBAØ: colonies are greyish to yellow dull, umbonate, often β-hemolytic and range in size from 0.5 to 2 mm, and they produce greening of the agar upon exposure to air.

      Lipase positive strains are often β-hemolytic

      BBEØ: no growth

      Fluorescentie/Woodslamp chartreuse / yellow-green

  • Characteristics

  • References

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